#OPENACCESS: The impact of glycosylation on the conformational ensembles of β-, δ-, and γ-sarcoglycans. Elham Fazelpour, Gabriel A. Cook, and Martin McCullagh.
Now predict and evaluate RNA 3D structure more accurately with a new and efficient statistical potential, TriRNASP – benchmarked on extensive test data sets.
Special issue call for papers: Single-Molecule Approaches to Reveal Structural and Mechanistic Properties of the Genome. buff.ly/bmxlsrE
Biophysical Journal
Special issue call for papers: Physical Properties of Cells: From Measurement to Medicine, A Tribute to Jochen Guck. buff.ly/GblFB1g
#OPENACCESS: Imagine a leaky house where the pumps never stop running. In sickle cells, hyperactive Piezo1 channels increase ion leaks and force cells to burn more fuel (lactate), revealing a hidden metabolic cost of mechanical stress.
Li et al. combine simulations and theory to study how the cytoskeleton regulates membrane protein phase separation during cell adhesion, showing that steric hindrance and membrane protrusive forces can drive membrane condensation together, tuning receptor-ligand interactions.
Hypoxic cancer cells are like race cars driving on flat tires. This study shows that a protein called kindlin-2 helps determine how prostate cancer cell membranes respond under low oxygen, influencing their mechanical resilience and behavior.
#OPENACCESS: Dielectrophoresis reveals stimulus-induced remodeling of insulin granule subpopulations. Ashley Archambeau, Teji Korma, Aneesh Deshmukh, Mark A. Hayes, and Kate L. White.
#OPENACCESS: Cells don’t just communicate through calcium waves; nematic cell alignment shapes how information propagates. Winterstrain et al. show that nematic defects can desynchronize signaling, with calcium waves traveling fastest when perpendicular to tissue orientation.
In the New and Notable "The cytoskeleton as an active regulator of membrane-protein condensation: A mesoscale simulation study." Yukang Zhang and Dechang Li highlight the paper "Cytoskeleton-regulated condensation of integral membrane proteins during cell adhesion."
Biophysical Journal
Biophysical Journal
Tissues rely on supracellular signals to coordinate their cells over a long range. Two such tissue-scale cues are calcium waves and patterns of cell-cell alignment or nematic order. During wound…
Glycosylation is a pivotal post-translational modification that influences protein folding, stability, and interactions with direct implications for muscular dystrophy pathogenesis and emerging gene…
Cell-to-cell adhesion is much more than simply the mechanical gluing together of adjacent surfaces; it is a fundamental process that underpins the structural integrity and functional identity of…
