Associate prof comp biologist @JHUBME. Founder @cuSTEMized. Editor @PLOSCompBiol. Alum @HarvardDBMI @blairmagnet. Doing art like a science, science like an art.
Dr. Jean Fan
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Our spatiotemporal transcriptomic analysis thus identified coordinated molecular changes within metabolic pathways deep within the cold ischemic kidney, highlighting potential opportunities for new insights beyond those available from superficial biopsy-focused tissue examinations.
Increased durations of cold ischemia is implicated in poor transplant outcomes, but the molecular mechanisms remain unclear. Using spatial transcriptomics, we profiling cold ischemia injury using a mouse model to identify temporally-resolved gene expression changes in a compartment-specific manner.
Dr. Jean Fan
What's your "scientific origin story"? In this video essay, I share mine from a keynote to graduating high school students: youtu.be/JXXIilLEmSg
Every story has an origin, including yours. Through education, you gain the skills to shape this story & choose which parts you may one day like to share.
In this blog post, I demo how I went from a question
➡️ "how have gas prices changed in different regions across the US over time?"
➡️ to using AI to find relevant data
➡️ to using AI to vibe code this data visualization to answer my question: jef.works/blog/2026/05...
Try it out for yourself!
Our spatiotemporal molecular analysis reveals an unexpected metabolic response: genes involved in oxygen-dependent oxidative phosphorylation are upregulated in the hypoxic inner medulla, a region that typically relies on glycolysis. Now corroborated by protein-level evidence from immunofluorescence.
Before cameras, only painters could "capture reality." After, people said cameras would replace painters. But painting evolved.
Now, people say AI will replace programmers. So, I reflect on things painting in the age of cameras can teach us about coding in the age of AI: jean.fan/2026/04/22/a...
