Rhinovirus triggers distinct host responses through differential engagement of epithelial innate immune signaling @ellenfoxman.bsky.social @yalepress.bsky.social
www.cell.com/cell-press-b... @cellpressblue.bsky.social
Thank you to Bob McDonald for hosting me on @CBCRadioCanada to discuss our work @yaleschoolofmed.bsky.social on what leads to variation in common cold virus infections and how we tackled this using nasal organoids. Listen here: www.cbc.ca/listen/live-...
#Interferons protect against #ViralInfection, but can hinder tissue repair - how? @ellenfoxman.bsky.social &co show that high IFN levels suppress #BronchialCell migration & proliferation during tissue repair via JAK-driven LATS1 activation, independent of STAT1 @plosbiology.org 🧪 plos.io/4k1pyKA
#Interferons protect against #ViralInfection, but can hinder tissue repair - how? @ellenfoxman.bsky.social &co show that high IFN levels suppress #BronchialCell migration & proliferation during tissue repair via JAK-driven LATS1 activation, independent of STAT1 @plosbiology.org 🧪 plos.io/4k1pyKA
Mechanistic insights into the impact of prenatal viral infections on maternal and offspring immunity
www.nature.com/articles/s44...
Frequent presymptomatic household transmission of influenza A but not influenza B virus
www.nature.com/articles/s44...
Excited to see this beautiful image of nasal #organoids featured as biomedical Image of the day by @cellpress.bsky.social 🙏🙏🙏 See full paper @cellpressblue.bsky.social #respiratory #lungs #EpithelialMechanics #IdSky #MedSky #ImmunoSky
#Epithelialmechanics fans...interferons protect against viruses but also impair recovery post-infection. In new work @plosbiology.org we show that interferons block epithelial repair by co-opting the Hippo pathway #innateimmunity #lungs #respiratory journals.plos.org/plosbiology/...
#InterferonFriendsOrFoes? Another cool one @ellenfoxman.bsky.social &friends out @plosbiology.org about how excessive #IFNs delay repair by activating LATS & degrading YAP/TAZ in the Hippo 🦛 pathway! journals.plos.org/plosbiology/... 👇👇👇
npj Viruses - Mechanistic insights into the impact of prenatal viral infections on maternal and offspring immunity
www.nature.com
Based on two waves of data collection from 748 households in Hong Kong, this analysis sheds light on the number of transmission events that occurred before manifestation of symptoms in influenza A and...
www.nature.com
Ever wonder why some people get really bad colds and others never get sick? Modeling the cells in human noses and lungs suggests an answer.
Interferons (IFNs) initiate antiviral defence when infected cells sense a virus protecting against infection via JAK/STAT signaling, but can hinder recovery by impairing tissue repair by an unknown me...
Interferons (IFNs) initiate antiviral defence when infected cells sense a virus protecting against infection via JAK/STAT signaling, but can hinder recovery by impairing tissue repair by an unknown me...
Response to rhinovirus depends on levels of interferon production & viral load – differences revealed using a nasal organoid
📷 Julien Amat & Bao Wang, relating to B.Wang et al article
@yaleschoolofmed.bsky.social in @cellpressblue.bsky.social
➡️ bpod.org.uk/archive/2026... with
@rooph.bsky.social
#Interferons protect against #ViralInfection, but can hinder tissue repair - how? @ellenfoxman.bsky.social &co show that high IFN levels suppress #BronchialCell migration & proliferation during tissue repair via JAK-driven LATS1 activation, independent of STAT1 @plosbiology.org 🧪 plos.io/4k1pyKA
