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Congrats to @jieyang437.bsky.social & Rahul for this awesome work on metastasis www.nature.com/articles/s41...
Research Highlight of our recent paper by @jieyang437.bsky.social on Aspirin and cancer metastasis in Nature Reviews Immunology. Thanks to Yvonne Bordon for a crystal clear account of the experimental findings www.nature.com/articles/s41...
Mar 25, 2025
Mar 6, 2025
Drugs like aspirin can enhance the anti-metastatic activity of T cells by blocking a platelet-mediated pathway of suppression.
www.nature.com
www.nature.com
Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.
Aspirin helps T cells to stop cancer spread - Nature Reviews Immunology
Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity - Nature
Roychoudhuri Lab
Seth Coffelt
One week left to apply for the postdoc position in my lab at Oxford @ox.ac.uk Join our exciting cancer immunology research at @oncology.ox.ac.uk, @oxfordcancer.bsky.social & @oxcio.bsky.social. Deadline: 11 August 2025 (noon).
We're recruiting a postdoc to join my lab at @oncology.ox.ac.uk & @oxcio.bsky.social to understand immune regulation in cancer and develop new approaches for cancer prevention and metastasis. Deadline: 11 August 2025 my.corehr.com/pls/uoxrecru... Lab info: www.oncology.ox.ac.uk/team/jie-yang
11mo
10mo
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Jie Yang
Jie Yang
We're recruiting a postdoc to join my lab at @oncology.ox.ac.uk & @oxcio.bsky.social to understand immune regulation in cancer and develop new approaches for cancer prevention and metastasis. Deadline: 11 August 2025 my.corehr.com/pls/uoxrecru... Lab info: www.oncology.ox.ac.uk/team/jie-yang
11mo
Brilliant new paper from Jie Yang @jieyang437.bsky.social and Rahul Roychoudhuri @roychoudhurilab.bsky.social linking aspirin to immune-mediated prevention of cancer metastasis. www.nature.com/articles/s41...
Mar 5, 2025
Jie Yang
my.corehr.com
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Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.
www.nature.com
Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity - Nature
New results from the ALASCCA prospective randomised controlled trial showing daily #aspirin reduces colorectal cancer recurrence by ~50% in patients with PIK3CA or related mutations. Findings extend benefits of aspirin beyond Lynch syndrome cancers to nearly 40% of CRCs ascopubs.org/doi/10.1200/...
Mar 25, 2025
Klaus Okkenhaug
LBA125Background: Colorectal cancer (CRC) affects 1.9 million individuals globally each year. Among patients with stage II-III CRC, 20-40% develop metastatic disease. Aspirin lowers the incidence of a...
Roychoudhuri Lab
ascopubs.org
Low-dose aspirin to reduce recurrence rate in colorectal cancer patients with PI3K pathway alterations: 3-year results from a randomized placebo-controlled trial.