This work uncovers how early-life crosstalk between commensal microbes and myeloid immune cells in the developing skin barrier is pivotal in shaping long-term tissue health and in preventing chronic inflammatory disease.
Significant highlights:
1. We identify that commensal microbes recruit monocytes to the neonatal skin
2. Disruption in this early-life accumulation of monocytes leads to spontaneous production of the inflammatory cytokine IL-17 from T cells later in life
3. Loss of monocytes in early-life leads to an increased susceptibility to psoriasiform inflammation in adulthood
4. Neonatal monocytes regulate IL-1 signaling to suppress spontaneous IL-17 production from cutaneous T cells.
Grateful for this fun group of scientists that joined me this year in building our new lab! Happy holidays from the Dhariwala Lab 🎄🎁🎊❄️