New paper from Will Gibson's lab showcases how induced proximity can be used to induce targeted protein mislocalization as a strategy to trigger cancer cell death.
Interesting, very interesting!!!!!
www.nature.com/articles/s41...
Exploiting the high abundance of mutant p53 protein, a small molecule was developed that specifically binds to p53-Y220C mutants and delivers a mitosis blocker, killing TP53-mutant cancer cells while ...
