1️⃣ Cortical alpha- and beta-band modulations are largely expressed in motor neuron output, including in task-irrelevant pools
2️⃣ These inputs primarily increase motor neuron synchronization
3️⃣ This synchronization facilitates the rapid build-up of drive after a sudden increase in excitatory input
🆕 🚩 New preprint on #bioRxiv by F. Dernoncourt .
We introduce a conceptually new framework that combines large-scale human motor unit recordings with simulation-based inference to estimate recurrent inhibition during voluntary contractions in humans.
🔗 Preprint:
www.biorxiv.org/content/10.6...
francoishug.bsky.social et al. investigated non-homogeneous distribution of inhibitory inputs among #motor units in response to #nociceptive stimulation at moderate contraction intensity ⚙️ ✍️
📜 Read the #Research here: https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP288504
🆕 🚩Brain oscillations may shape the functional state of the motor system, beyond the muscles directly involved in the task
New #Preprint with EEG and large-scale motor neuron recordings
🔗 shorturl.at/p2jjI
@clementnaveilhan.bsky.social FDernoncourt WvandenHoorn #Neuroscience #MotorControl #EEG #EMG
The pipeline is openly available and readily extensible to other spinal circuits, motor tasks, and clinical populations
💻 All code: github.com/FrancoisDern...
📊 Data (raw EMG + edited MU spike trains): Figshare
#OpenScience #OpenData #Neuroscience #EMG #Motorneuron #MotorUnit #SpinalCircuit
Key findings:
1️⃣ A validated simulation-based inference pipeline providing probabilistic estimates of recurrent inhibition from observable motor unit spiking features.
2️⃣ Application to six human muscles revealing previously uncharacterized muscle- and intensity-dependent patterns.
We combined experimental data + simulation to study how nociceptive stimulation affects motor unit behavior during moderate contractions.
Our findings challenge the traditional view of uniform inhibition and provide new insights into how the nervous system adapts to pain during muscle contraction.
🆕📝 New publication in @jphysiol.bsky.social “Non-homogeneous distribution of inhibitory inputs among motor units in response to nociceptive stimulation at moderate contraction intensity”
🔗 doi.org/10.1113/JP28...
@univcotedazur.bsky.social @simonavrillon.bsky.social @agencerecherche.bsky.social