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Professor in Human Movement Science (Univ Côte d’Azur, France), Hon IUF junior fellow, Hon Prof Univ Queensland

François Hug

Key findings: 1️⃣ A validated simulation-based inference pipeline providing probabilistic estimates of recurrent inhibition from observable motor unit spiking features. 2️⃣ Application to six human muscles revealing previously uncharacterized muscle- and intensity-dependent patterns.

francoishug.bsky.social‬ et al. investigated non-homogeneous distribution of inhibitory inputs among #motor units in response to #nociceptive stimulation at moderate contraction intensity ⚙️ ✍️ 📜 Read the #Research here: https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP288504

The CEDE website is now up and running. Designing an experiment using EMG? Then check out this website and try the decision support tool: cede.isek.org

We combined experimental data + simulation to study how nociceptive stimulation affects motor unit behavior during moderate contractions. Our findings challenge the traditional view of uniform inhibition and provide new insights into how the nervous system adapts to pain during muscle contraction.

1️⃣ Cortical alpha- and beta-band modulations are largely expressed in motor neuron output, including in task-irrelevant pools 2️⃣ These inputs primarily increase motor neuron synchronization 3️⃣ This synchronization facilitates the rapid build-up of drive after a sudden increase in excitatory input

🆕📝 New publication in @jphysiol.bsky.social “Non-homogeneous distribution of inhibitory inputs among motor units in response to nociceptive stimulation at moderate contraction intensity” 🔗 doi.org/10.1113/JP28... @univcotedazur.bsky.social @simonavrillon.bsky.social @agencerecherche.bsky.social

The pipeline is openly available and readily extensible to other spinal circuits, motor tasks, and clinical populations 💻 All code: github.com/FrancoisDern... 📊 Data (raw EMG + edited MU spike trains): Figshare #OpenScience #OpenData #Neuroscience #EMG #Motorneuron #MotorUnit #SpinalCircuit

🆕 🚩Brain oscillations may shape the functional state of the motor system, beyond the muscles directly involved in the task New #Preprint with EEG and large-scale motor neuron recordings 🔗 shorturl.at/p2jjI @clementnaveilhan.bsky.social FDernoncourt WvandenHoorn #Neuroscience #MotorControl #EEG #EMG

🆕 🚩 New preprint on #bioRxiv by F. Dernoncourt . We introduce a conceptually new framework that combines large-scale human motor unit recordings with simulation-based inference to estimate recurrent inhibition during voluntary contractions in humans. 🔗 Preprint: www.biorxiv.org/content/10.6...