How do electrostatic forces impact TF search ? In joint effort with @beatfierz.bsky.social , tour-de-force from @simsakong.bsky.social who single-handedly combined in vitro SPT on DNA & chromatin, in cellulo SPT, ChIP-seq and ATAC-seq www.nature.com/articles/s41...
This work describes how positive charge in the peptide chain flanking the DNA-binding domain of transcription factors speeds up their search on free and chromatinized DNA, helping to explain why some ...
