📢 New preprint alert ! www.biorxiv.org/content/10.6...
Joanna Dembska developed a highly scalable image-base screening platform for protein turnover modulators in human neurons, based on our fluorescent timer system. Protein turnover is perturbed in nearly all neurodegenerative diseases ...
Postdoc position available now in the Smith Group lsi.exeter.ac.uk/groups/smith... to test the hypothesis that differentiation biases between human pluripotent stem cell lines may be eliminated by reversion to the naïve state.
careers.exeter.ac.uk/vacancies/79...
How do these compounds act ? Despite the fact that their known cellular targets are all different from each other, we found that all three compounds converged on inducing an increase in ribosomal protein expression, suggesting that enhancing protein synthesis may in turn stimulate protein turnover.
David Suter
Austin Smith
human models of alpha-synuclein mediated protein aggregation (model of Parkinson's disease). All 3 compounds were able to strongly reduce the formation of pathological fibrils in mouse neurons, and one was also potent in human ES cell-derived dopaminergic neurons...
and is involved in the formation of toxic aggregates. Joanna screened for nearly 6000 compounds, and found nearly 200 compounds increasing turnover in human neurons. After narrowing down the list, she focused on three compounds that were further tested by Anne-Laure Mahul-Mellier in mouse and...
Big 🙏 to everyone involved, first to fantastic Joanna Dembska who put so much hard work into this project, to AL Mahul-Mellier for the beautiful work on the PD disease models, and to the EPFL bioimaging, proteomics, genomics, & biomolecular screening facilities.
Help please! We need to do some large(ish) cell culture inhibiting E-cadherin with a monoclonal antibody. Does anyone have the DECMA-1 hybridoma cell line so we could purify our own antibody? or a similar monoclonal that would do the job. Any help greatly appreciated, just DM me. Please repost!
