New from the Cravatt Lab!
Tryptoline stereoprobes reveal hidden cysteine ligandability: while Boltz-2 nails orthosteric sites but burns out on non-orthosteric ones.
A masterpiece of chemoproteomics + AI.
š doi.org/10.1101/2025...
Activity-based protein profiling has identified hundreds of proteins from diverse classes that react at specific cysteine residues with stereochemically defined electrophilic compounds (stereoprobes) ...
