I rarely get to give a research talk at my home institution! Looking forward to giving a talk about our latest research next Tuesday, November 18th, at 2 pm as part of the @innovativegenomics.bsky.social seminar series in Room 115 IGIB at UC Berkeley! innovativegenomics.org/events/semin...
Excited to highlight our latest bioRxiv led by grad student Zoe Duong and Qian Shao. We report a chemistry-centric, chemoproteomics-enabled strategy to discover non-degradative molecular glues for transcriptional rewiring. 🔗 www.biorxiv.org/content/10.6...
New preprint out! We show that PROTAC-induced ubiquitination can bypass canonical ERAD to degrade ER membrane proteins. Wonderful collaboration w/ @dannomura.bsky.social and huge credit to grad student superstar Sydney Tomlinson!
www.biorxiv.org/content/10.1...
Induced proximity-based therapeutic modalities
nature.com/articles/s41...
rdcu.be/eOfBH
This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
TRACERs enable epigenetic silencing of transcription factors through fully small-molecule control.
We demonstrate that TRACERs can potently and selectively repress the transcriptional programs of estrogen receptor (ER) and androgen receptor (AR/AR-V7).
This establishes a new therapeutic modality - using small-molecule-induced proximity for targeted epigenetic reprogramming - to silence transcriptional networks long considered out of reach.
A potential blueprint for pharmacologically “turning off” disease-driving transcription factors.
Dan Nomura
Dan Nomura
In androgen-independent prostate cancers expressing both AR and the “undruggable” truncation variant AR-V7, where AR antagonists inhibit only ~40% of AR activity...
Our AR/AR-V7 TRACER, which links an AR SARM to an MBD2 recruiter, suppresses more than 90% of AR transcriptional activity.
We unveil TRACERs, Transcriptional Regulation via Active Control of Epigenetic Reprogramming: a new small-molecule-based induced-proximity modality that silences transcription factors by recruiting endogenous corepressor complexes for locus-specific repression.
www.biorxiv.org/content/10.1...
New from the Cravatt Lab!
Tryptoline stereoprobes reveal hidden cysteine ligandability: while Boltz-2 nails orthosteric sites but burns out on non-orthosteric ones.
A masterpiece of chemoproteomics + AI.
🔗 doi.org/10.1101/2025...
Huge congrats to first author @cestieger.bsky.social for leading this effort! Thanks to @novartis.bsky.social and @themarkfdn.bsky.social for their support.
#MolecularTherapeuticsInitiative #BerkeleyChemistry #BerkeleyMCB
James Olzmann
Nature Reviews Drug Discovery
Dan Nomura
Reimagining Druggability using Chemoproteomic Platforms - Innovative Genomics Institute (IGI)
Transcriptional reprogramming through induced proximity has emerged as a powerful strategy for modulating the expression of oncogenic and tumor-suppressive genes. Inspired by transcriptional reprogram...
