High-Dose Vitamin C in Burns
Time to Stop
🆕🔥🟢VICTORY RCT
High-dose intravenous vitamin C did not reduce mortality and organ dysfunction and may be associated with harm in patients with severe burn injury #EMIMCC
jamanetwork.com/journals/jam...
No different. Bacteria are still just bacteria.
I see stuff like this as less about dogma being wrong or bad but rather: we do the best we can until data beats physiology
New in @cmijournal.bsky.social:
"Which trial do we need? Evaluating plasma microbial cell-free DNA in blood culture-negative infective endocarditis"
#IDSky @absteward.bsky.social
www.clinicalmicrobiologyandinfection.org/article/S119...
Patients in the anti-MRSA Ceph + DAP arm had a 59.9% (95% CI, 52.4%–67.4%) probability of having a better outcome than those in the OAR arm. Esp, anti-MRSA Ceph +DAP was associated with reduced mortality (aHR, 0.54 [95% CI, .34–.85]), confirmed after adjustment with IPTW analysis #idsky
No statistically significant mortality difference between groups with the upper bound of the confidence intervals being below the initial BALANCE trial’s 4% non-inferiority margin
For years, the need for longer durations in immunocompromised patients was treated as the exception to every shorter-duration bacteremia discussion.
BALANCE may have finally put that belief to rest.
Dogma continues to lose ground. #idsky
🆕🔥🟢Post hoc subgroup analysis of the BALANCE RCT 7 Vs 14d duration of antibiotic therapy for bacteremia in immune compromised hosts
1037 immune compromised patients #idsky
www.clinicalmicrobiologyandinfection.org/article/S119...
🆕🔥🟢Excellent review article
Carbapenemases: epidemiology, detection & management in a changing global landscape
🔺Carbapenemase classification.
🔺Characteristics of key carbapenemase families
🔺Geographic distribution
🔺Guideline-based treatment recommendation #idsky
academic.oup.com/jacamr/artic...
This international randomized clinical trial evaluates the efficacy of high-dose intravenous vitamin C in reducing 28-day mortality and persistent organ dysfunction (dependence on mechanical ventilati...
