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Transient RNA structures play a key role in the emergence of highly pathogenic avian influenza viruses! Great to see this collaboration with Mathis Funk, Mathilde Richard, Stephen Cusack, and others in @science.org www.science.org/doi/10.1126/...
Now out in Science Advances: www.science.org/doi/10.1126/...
3-year-old girl dies from H5N1 bird flu in Mexico’s first human case bnonews.com/index.php/20...
Flu infection => temperature⬆️ => NP levels⬇️ => aberrant RNAs⬆️ => interferon⬆️. Elegant modeling and experimental work by @karishmabisht.bsky.social and @danielweilandt.bsky.social! Preprint: www.biorxiv.org/content/10.1...
RNA structure modulates Cas13 activity and enables mismatch detection - @cambearon.bsky.social @princetonmolbio.bsky.social go.nature.com/4oglebG
7mo
May 20, 2025
3mo
5mo
Apr 8, 2025
A three-year-old girl who became Mexico’s first confirmed human case of H5N1 avian influenza has died, the country’s Health Ministry announced. It marks Mexico’s first fatality linked to the bird flu ...
bnonews.com
Fever promotes aberrant influenza A virus RNA synthesis and innate immune activation.
www.science.org
www.biorxiv.org
3-year-old girl dies from H5N1 bird flu in Mexico’s first human case
Febrile temperature activates the innate immune response by promoting aberrant influenza A virus RNA synthesis
An effective CRISPR RNA occlusion strategy enhances mismatch detection when using Cas13.
go.nature.com
Highly pathogenic avian influenza viruses (HPAIVs) derive from H5 and H7 low pathogenic avian influenza viruses (LPAIVs). Although insertion of a furin-cleavable multibasic cleavage site (MBCS) in the...
www.science.org
RNA structure modulates Cas13 activity and enables mismatch detection - Nature Biotechnology
Polymerase trapping as the mechanism of H5 highly pathogenic avian influenza virus genesis
AJ te Velthuis
AJ te Velthuis
AJ te Velthuis
Nature Biotechnology
BNO News
Congratulations to @karishmabisht.bsky.social with her paper on the effect of fever on influenza replication and innate immune activation! www.science.org/doi/10.1126/...
5mo
Febrile temperature activates the innate immune response by promoting aberrant influenza A virus RNA synthesis
Fever promotes aberrant influenza A virus RNA synthesis and innate immune activation.
www.science.org
AJ te Velthuis
Excited to share our latest preprint in which we integrate mathematical modeling with experimental approaches to investigate how ⬆️ temperature influences aberrant RNA synthesis and innate immunity in flu infection 🦠
There is still time to apply; join our team to work on influenza virus replication mechanisms!
May 20, 2025
May 26, 2025
Decoding influenza virus: From polymerase mechanisms to translational therapeutics www.sciencedirect.com/science/arti...
4mo
Flu infection => temperature⬆️ => NP levels⬇️ => aberrant RNAs⬆️ => interferon⬆️. Elegant modeling and experimental work by @karishmabisht.bsky.social and @danielweilandt.bsky.social! Preprint: www.biorxiv.org/content/10.1...
Karishma Bisht
May 20, 2025
Ervin Fodor
Ervin Fodor
www.biorxiv.org
AJ te Velthuis
Exciting job opportunities! Two postdoc positions are available in the Fodor Lab at @dunnschool.bsky.social to study influenza virus transcription, genome replication, nuclear export and assembly. More info: my.corehr.com/pls/uoxrecru...
May 7, 2025
Ervin Fodor