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Systematic Review: Greater exposure to adverse #SocialDeterminants was associated with #neurobiological abnormalities in #Schizophrenia spectrum conditions, linking SDOHs to clinical outcomes and supporting equity-oriented approaches. ja.ma/4aFiKyW
Serial bias in spatial working memory differed by group, with patients with schizophrenia showing repulsive bias, most healthy controls showing attractive bias, and individuals with bipolar disorder demonstrating mixed patterns. ja.ma/4e7AIfH
Targeted psychological and psychosocial interventions for #Schizophrenia, including avatar therapy, reduced the severity of #AuditoryHallucinations with small to medium effects and high acceptability. ja.ma/4eCkrhP
📝 Narrative Review: Low-dose #Lithium exposure is linked to neuroprotective effects, reduced #Dementia risk, and cognitive stabilization in mild cognitive impairment, supporting further clinical evaluation. ja.ma/4efWI6Y
Targeted psychological and psychosocial interventions for #Schizophrenia, including avatar therapy, reduced the severity of #AuditoryHallucinations with small to medium effects and high acceptability. ja.ma/4eaNSIU
In adults with methamphetamine use disorder, mirtazapine reduced methamphetamine use by approximately two more days per month vs placebo, with no unexpected safety concerns. ja.ma/4e5qlJo
Administration of ketamine during general anesthesia preserved high-frequency EEG changes but lacked low-frequency modulation, suggesting neurophysiologic components of ketamine can be selectively altered. ja.ma/4e6qA6X
📝 Narrative Review: Low-dose #Lithium exposure is linked to neuroprotective effects, reduced #Dementia risk, and cognitive stabilization in mild cognitive impairment, supporting further clinical evaluation. ja.ma/4xpBdtk
This narrative review suggests mental disorders are statistical clusters of biopsychosocial properties, not sharply defined categories, mirroring concepts in species classification and supporting dimensional #MentalHealth frameworks. ja.ma/4xw5dDO
Disrupted gastrointestinal interoception predicted relapse and symptom severity in weight-restored females with #AnorexiaNervosa, supporting ingestible mechanosensory probes as scalable tools for monitoring and relapse prevention. ja.ma/4a4UDcM
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JAMA Psychiatry
Evolution of Lithium as a Disease-Modifying Agent in Dementia
This narrative review synthesizes more than 75 years of evidence to evaluate lithium's evolution from mood stabilizer to candidate neuroprotective intervention.
ja.ma
ja.ma
This narrative review synthesizes more than 75 years of evidence to evaluate lithium’s evolution from mood stabilizer to candidate neuroprotective intervention.
Evolution of Lithium as a Disease-Modifying Agent in Dementia