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JAMA Psychiatry
📝 Narrative Review: Low-dose #Lithium exposure is linked to neuroprotective effects, reduced #Dementia risk, and cognitive stabilization in mild cognitive impairment, supporting further clinical evaluation.
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In #StimulantUseDisorder trials, no medication significantly outperformed placebo for abstinence, but cabergoline supported greater reduced cocaine use when nonabstinence outcomes were included.
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In adults with methamphetamine use disorder, mirtazapine reduced methamphetamine use by approximately two more days per month vs placebo, with no unexpected safety concerns.
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In Denmark, average genetic risk among individuals diagnosed with #ADHD or #AutismSpectrumDisorder declined over two decades, supporting broadening diagnostic criteria as the main driver of rising rates.
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In #StimulantUseDisorder trials, no medication significantly outperformed placebo for abstinence, but cabergoline supported greater reduced cocaine use when nonabstinence outcomes were included. ja.ma/4ujetrY
Exposure to #ChildhoodTrauma was linked to #BipolarDisorder in part via reduced volume of the hippocampus and thinner cortex in the medial orbitofrontal and superior frontal gyrus. ja.ma/4vFVw3W
💬 Editorial: Reduced temporal stability of #EEG microstates shows promise as a scalable biomarker for predicting clinical outcomes in individuals at high risk for psychosis.
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Consideration of statistical, impairment, prediction, and cost-benefit approaches for clinical-decision thresholds in #Psychiatry may enhance risk assessment and treatment selection beyond diagnosis-based cutoffs.
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For patients with #FirstEpisodePsychosis unresponsive to initial antipsychotic therapy, clozapine improved symptom response rates and reduced discontinuation due to insufficient efficacy vs olanzapine or amisulpride. ja.ma/49JXqYR
Among adults with treatment resistant #depression, single-day inhaled GH001 resulted in rapid, significant symptom reduction and remission vs placebo, with no severe adverse events and sustained effects over 6 months.
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