Biotech. Interests: oncology, transcription, RNA, small molecule drug discovery, RNA therapeutics, protein aggregation, phase transitions
Bede Portz
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Finally out in @Cellcellpress!
Proteins with long IDRs are prone to misfolding during protein synthesis.
This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones.
www.cell.com/cell/fulltex...
www.biorxiv.org/content/10.6...
www.cell.com/cell/fulltex...
Came across this really cool compendium of AI foundation models of life science curated by @neuromusic.bsky.social and had to share. bio.rodeo
👀
Long wondered if the rules being elucidated in the nucleous apply more broadly to transcriptional condensates? Talked about this with @superscijew.bsky.social over the years. Thoughts? Congrats on paper.
ft. Katie Copley, Ashleigh Smirnov, Leland Mayne, Miriam Linsenmeier, Jack Rubien, @ysptsps.bsky.social, Bo Lim Lee, Hana Odeh, Longsheng Lai, @yiweichang.bsky.social, Ben Black & James Shorter (BioBio) @science.org www.science.org/doi/10.1126/...
🆕 review with @jpunfried.bsky.social out in Nature SMB. Direct roles of lncRNAs in transcriptional activation. What do we understand about how lncRNAs lure Pol2 and set the stage for RNA production, and what do we still miss? www.nature.com/articles/s41...
www.cell.com/cell/fulltex...
Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically
disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis
of fully active proteins.
A deep learning method quantitatively decodes nucleolar, nuclear speckle, and viral
condensate morphology to reveal underlying biochemical states. Applying this framework
reveals a previously unrecogn...
www.cell.com
This Review discusses how long noncoding RNAs (lncRNAs) control transcription activation by RNA polymerase II, including how they are produced at active enhancers or chromatin-domain boundaries and ac...
If you are interested in mechanistic aspects of transcription regulation and mRNA processing, check out this fantastic EMBO Workshop in Oxford, UK in September 2026.
Registration is closing soon!
Intrinsically disordered protein regions (IDPs) are found across the tree of life and characterized by the lack of a stable 3D fold, encoding function through a vast ensemble of conformations. This pl...
www.biorxiv.org
Christine Mayr
bio.rodeo
Honest evaluations of biological foundation models. We rank and review AI for protein folding, genomics, single-cell analysis, and more.
See our handy graphical abstract and article for free here:
bit.ly/4vsl845
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes:
🖌️ Dozens more images with duplications or painting
🖨️ Hundreds of blots that all share the same background (behold slideshow below)
Video
Reese Richardson
CRISPR perturbation of ∼4 million gene pairs in human HAP1 cells maps ∼89,000 genetic
interactions, revealing a hierarchical network that links genes to complexes, pathways,
and cellular processes and...
Check out our new work in Cell Systems @cp-cellsystems.bsky.social! Much of the biochemistry in the cell is organized by biomolecular condensates, but what mechanisms control the distribution of a given condensate throughout the cell? And is this mesoscale organization important for function?
Jon Henninger
Jon Henninger
How are biomolecular condensates spatially organized? As example, we focus on fibrillar centers producing ribosomal RNA in the nucleolus. Disrupting this function disrupts their patterning, and disrupting patterning disrupts function. Out in Cell Systems: authors.elsevier.com/c/1nA3C8YyDf... (1/6)
