Huge thanks also to my colleague and friend @divyach.bsky.social , who uncovered a deterministic source of phenotypic heterogeneity in the UH response using machine learning.
#MicroSky
And to Khalid El Karkouri, our @lcbofficiel.bsky.social bioinformatician, who showed the conservation of this newly identified system across E. coli strains.
This work was a true collaboration across disciplines:
Microbiology with @ben-ezraty.bsky.social group, reactive chemistry with Sylvia Pietri’s group (ICR, Marseille), and infection biology with @sewinter.bsky.social , who helped reveal the in vivo relevance of this system.
Inflammation can turn uric acid into a reactive oxidant.
We found that E. coli survives this stress using HiuH, an enzyme that directly detoxifies urate hydroperoxide and protects bacteria in the inflamed gut.
👇👇👇 NEW PREPRINT ONLINE 👇👇👇
www.biorxiv.org/content/10.6...
#NewPreprint
#Microbiology #Inflammation #GutMicrobiome
Unveiling hidden variables in stressed bacteria: Cell Reports www.cell.com/cell-reports...
Thrilled to see our review out in @cp-cellreports.bsky.social !
With @divyach.bsky.social, we explore the structured side of biological noise, and what it means for understanding bacterial phenotypic heterogeneity.
Video
Maxence Vincent
Maxence Vincent
Maxence Vincent
Noise in bacterial stress responses is often dismissed as mere randomness. While true
stochasticity exists, much variation reflects hidden variables—cell state, history,
and microenvironment—that are ...
1/ With @maxencevincent.bsky.social, we ask: when single bacterial cells behave differently under stress, is it really just “noise”?
Read more @cp-cellreports.bsky.social :
Unveiling hidden variables in stressed bacteria (doi.org/10.1016/j.ce...)
