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This dataset is paired with a spatial transcriptomic analysis of the locus coeruleus from the same donors. This work led by @berniejmulvey.bsky.social is also now in pre-print! bsky.app/profile/berniejmulvey.bsky.social/post/3m4isvuqabm2v www.biorxiv.org/content/10.1...
6mo
And of course thanks to @lcolladotor.bsky.social @kr-maynard.bsky.social @martinowk.bsky.social
Many exciting findings here inspire future work! Next we'll explore Oligo.3 to see if this signal is present in AD donors and check how upstream events in the circuit connecting the locus coeruleus and the ERC may drive disease. Keep an eye on @lieberinstitute.bsky.social for more AD research! 🧠
6mo
6mo
The strong AD risk signal in this #oligodendrocyte subtype prompted a closer look at the identity of Oligo.3. Marker genes and a trajectory analysis suggest Oligo.3 is a pre-myelinating oligodendrocyte, perhaps the earliest stage of oligos differentiating from OPCs