Thermo Fisher now has a page up in response to our observations. They flatly deny that images were manipulated or fabricated while repeating that images were "optimized for presentation and clarity on the website", no lie, six times.
www.thermofisher.com/us/en/home/l...
ALRIGHT EVERYONE HERE IS THE OFFICIAL SUFS GUIDE TO LEAVING PUBLIC COMMENTS ON THE OMB-2026-0034 PROPOSED RULE: www.standupforscience.foundation/policy-and-advocacy/the-sufs-guide-to-writing-public-comments
(share with all your friends!)
We found that Aβ fibrils at plaque edges form a complex with the U1 snRNP. U1-70k is the most-correlated insoluble protein with Aβ in AD. Previously thought to be intracellular in tangles, but we find it’s directly bound to Aβ. With @raflynn5.bsky.social. www.biorxiv.org/content/10.6...
Written by: Cole Donovan, Director of Policy and Advocacy and Colette Delawalla, PhD, CEO
www.standupforscience.foundation
On OMB's proposal to make all grants political:
"Speak up! Now’s the time! Standing by the side of the room, glancing around nervously and hoping that somebody else does something will lead us to disaster. These are not normal times, so stop acting as if they are."
www.science.org/content/blog...
There are so many tech companies now named after Lord of the Rings (Palantir, Anduril, Earendil…)
Very concerned that in 20 years tech will be disrupted by Hufflepuff Industries
Directional elements: the preprints are out! 1/n
Congratulations to our amazing team:
biorxiv.org/content/10.6...
biorxiv.org/content/10.6...
biorxiv.org/content/10.6...
We screened for principles governing global brain dynamics by developing a set of new methods: 1) conformal immersion microscopy;
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes:
🖌️ Dozens more images with duplications or painting
🖨️ Hundreds of blots that all share the same background (behold slideshow below)
Finally out in @Cellcellpress!
Proteins with long IDRs are prone to misfolding during protein synthesis.
This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones.
www.cell.com/cell/fulltex...
Kristian G. Andersen
Andrew Stern
Video
What is the largest source of electricity in each country?
Coal generates one-third of the world’s electricity, more than any other source.
But zoom into the country level, and the picture is much more varied.
www.biorxiv.org
NIH's Stadtman Investigator Program is back in 2026! As a Stadtman tenure-tracker myself, I cannot emphasize how important this program has been to the establishment of our lab in the intramural world. Take a look, ask me any questions you may have, and apply!
Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically
disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis
of fully active proteins.
