Happy to share the work by Fabienne Becker et al in #NAR, showing how yeast Tho1-CTD stimulates helicase activity of Sub2, homologue of human DDX39B/UAP56, by promoting Sub2 oligomerization on RNA. The scaffolding mechanism is shared across species:
academic.oup.com/nar/article/...
academic.oup.com
Abstract. DEAD-box helicases are essential for gene expression and RNA metabolism. However, the mechanisms regulating their activity remain largely elusive
