Accurate RNA structure prediction remains a challenge, despite recent computational advances. This study presents DRFold2, a #DeepLearning framework that significantly enhances accuracy of de novo #RNAstructure prediction by increasing contact prediction precision @plosbiology.org 🧪 plos.io/4aoOQiX
A new + interesting paper on the guanidine riboswitch in Synechocystis and other cyanobacteria:
"Deciphering guanidine assimilation and ri"boswitch-based gene regulation in cyanobacteria for synthetic biology applications" | PNAS www.pnas.org/doi/10.1073/...
„RAPDOR: Using Jensen-Shannon Distance for the computational analysis of complex proteomics dataset“ rdcu.be/eImcr : 11 authors from 3 labs. Many thanks to all for making this possible!
How to search for unknown RNA-binding proteins? We did GradR in the cyanobacterium Synechocystis 6803. And now our paper „RAPDOR: Using Jensen-Shannon Distance for the computational analysis of complex proteomics dataset“ is finally out in Nature Communications, here: rdcu.be/eImcr .
Riding a train in China, returning from the ISPP 2025 and the Green Carbon conference.
For the intuitive analysis + visualization of such datasets we introduce RAPDOR. In contrast to expression profiles, which are compared e.g. by correlation, the results of GradR and similar approaches are naturally displayed as distributions, as the protein fraction in each compartment is measured.
Riding a train in Lithuania.
RNA-binding proteins and photosynthesis: The RRM domain–containing protein Rbp3 interacts with ribosomes and the 3’ ends of mRNAs encoding photosynthesis proteins | PNAS www.pnas.org/doi/10.1073/...
We have been searching for novel RNA-binding proteins and validated, among many candidates, Sll1967 (a possible RlmD homolog), Sll0726 (phosphoglucomutase), Ssl2245 (a putative antitoxin), Slr0711 (possible QueF homolog), and Sll0947 (ribosome-associated inhibitor RaiA/LrtA homolog) as binding RNA.
