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Now published in Current Opinion in Genetics & Development as part of the special issue on Genome Architecture and Expression. 🧬 Part 1: doi.org/10.1016/j.gd... Part 2: doi.org/10.1016/j.gd...
29d
doi.org
Redirecting
Noa Ottilie Borst
🧬✨ New 2-part review on the evolution of regulatory DNA (enhancers & promoters)! What started as conversations between Gasper Tkačik @istaresearch.bsky.social and our group @embl.org grew into a broader synthesis. Preprints here: Part 1: arxiv.org/abs/2601.19681 Part 2: arxiv.org/abs/2601.21480
4mo
Promoters and enhancers are cis-regulatory elements (CREs), DNA sequences that bind transcription factor (TF) proteins to up- or down-regulate target genes. Decades-long efforts yielded TF-DNA interac...
arxiv.org
Long-term evolution of regulatory DNA sequences. Part 1: Simulations on global, biophysically-realistic genotype-phenotype maps
Justin Crocker