Chair 5th Med Dept UMM, Heidelberg University
Kidney Transplantation and Cell Death Biology
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Reviewing the paper by the Kats´ lab published today in #Cell, "Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia", I learned that cuproptosis is real! Here is my preview:
When heme is low, copper kills cancer:
www.cell.com/cell/fulltex...
Thrilled to have contributed to this work led by @jgcastillo.bsky.social during his PhD at UC Berkeley w/ Michel DuPage. Targeting FSP1 in T cells boosts anti-tumor immunity by relieving Treg suppression, revealing a new immunomodulatory therapeutic axis. www.science.org/doi/10.1126/...
Here is a link to our most recent editorial for #CDDiff, Cell Death and Differentiation. It´s on work by Tony Letai and team.
www.nature.com/articles/s41...
Nature research paper: Erythropoietin receptor on cDC1s dictates immune tolerance
go.nature.com/496nEob
Secondary Necrosis Following Caspase‐Activation can Occur Independently of Gasdermin E - Gavali - Advanced Science - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/10.1002/...
Obituary: David Baltimore (1938-2025) virologist whose enzyme discovery transformed understanding of cancer and HIV/AIDS
go.nature.com/443Vojo
Congrats to the wonderful Sid Balachandran and team!
www.nature.com/articles/s41...
Registration is open: register for the first #MMPUResearchDay taking place in #Mannheim at #CubexOne on Oct 13, 2025. A great line-up of scientists from #MMPU, #EMBL, #UMM, #UKHD.
Very pleased to share this "spotlight" in Trends in Endocrinology and Metabolism which refers to our recent work.
www.sciencedirect.com/science/arti...
Heme carries oxygen and is critical for the control of redox reactions. In this issue
of Cell, Lewis and Gruber et al. demonstrate how low concentrations of heme destabilize
complex IV of the respirat...
Tumor cell evasion from regulated cell death is a hallmark of cancer [1]. Davern et al. now identify resistance to mitochondrial apoptosis to represent the common mechanism by which persister cells th...
www.nature.com
The tolerogenic activity of type 1 conventional dendritic cells (cDC1s) is determined by EPOR, which is preferentially expressed in cDC1s and induces antigen-specific FOXP3-expressing regulatory T cells.
Secondary necrosis follows apoptosis, but its mechanism is unclear. This study shows that although gasdermin E is cleaved during this process, it is not required for membrane rupture. Across multiple...
The molecular mechanisms underlying sex differences in acute kidney injury (AKI) remain incompletely understood. In a study recently published in Natu…
