Why did severe #StrepA infections in children increase after the pandemic?
Our new @jamanetworkopen paper suggests COVID restrictions delayed immunity development in young children.
tiny.cc/63vt001
Putting our deductive, problem-solving, and team-working skills to good use - we had so much fun at the Sherlock Escape Room aaand we escaped in 53 minutes! #teampbp #escaperoom
We are only beginning to understand the breadth of enzyme diversity in the archaeal world. Here's an example of how an archaeon can deploy a phospholipase to kill certain bacteria...
www.biorxiv.org/content/10.6...
Applications for @ukri.org Medical Research Council funded MRes+PhD studentships in Interdisciplinary Health Sciences at @imperialcollege will open on Tuesday 7 October.
www.imperial.ac.uk/multisci-mrc...
#PhD #Interdisciplinaryhealthscience #Scholarships
The 2024 rankings of bacterial threats
This first-author publication is my… first! Archaea kill bacteria by targeting their Achilles’ heel: peptidoglycan. Big shoutout to @ahocher.bsky.social, @valeriesoo.bsky.social, Pauline Misson, @tobiaswarnecke.bsky.social and MRC LMS Proteomics. A thread 🔽
journals.plos.org/plosbiology/...
Researchers CBRB welcomed colleagues from WACCBIP as part of an Imperial Global Connect visit.
The event aimed to strengthen international partnerships and advance discovery research in bacterial antimicrobial resistance (AMR). 🔬
www.imperial.ac.uk/news/article...
Archaea-on-bacteria action! @romainstrock.bsky.social @tobiaswarnecke.bsky.social &co show that many #archaea encode #peptidoglycan hydrolases, which specifically target #bacterial cell walls, experimentally confirming the killing capacity of 2 of these enzymes @plosbiology.org 🧪 plos.io/4lrJBBa
The MIMIC lab is hiring a Postdoctoral Research Associate to join my team at @Cambridge_Uni!
Exploration and engineering DNA-mimicking proteins (wet-lab position.) 🧬
Details: www.jobs.cam.ac.uk/job/50652/
Please get in touch / circulate !
Very happy to see this work published + getting the recognition it deserves! Archaea are very cool + understudied organisms and we are only scratching the surface! Since the preprint last year, we (@romainstrock.bsky.social) have included more evidence of bacteria getting killed by archaeal arsenal.
This cross-sectional study examines changes in immunity to Streptococcus pyogenes and other common respiratory pathogens among young children in 10 European countries after the introduction of nonphar...
Archaea regularly interact with bacteria but reports of archaea killing bacteria are very rare. This study shows that many archaea encode peptidoglycan hydrolases, which specifically target bacterial ...
Archaea kill bacteria, at least on occasion. The molecular underpinnings of these lethal interactions are barely understood. Here, we describe cinquedea, an α/β hydrolase secreted by the halophilic ar...
Archaea are often surrounded by bacteria. But is there ever active conflict between the two? Can archaea kill bacteria? If so, how do they do it?
Work by @romainstrock.bsky.social shows that some archaea can kill bacteria by secreting peptidoglycan hydrolases. journals.plos.org/plosbiology/...
Archaea are the hornets of the microbial world. Discuss.
www.biorxiv.org/content/10.6...
TLDR: Archaeon kills bacterium with secreted phospholipase. Pretty nifty way to kill bacteria for a microbe with a very different lipid make-up, I reckon. No need to worry about accidentally killing yourself.
Archaea regularly interact with bacteria but reports of archaea killing bacteria are very rare. This study shows that many archaea encode peptidoglycan hydrolases, which specifically target bacterial ...
Awesome to see the transparent, systematic, and evidence-based approach behind the WHO Bacterial Priority Pathogens List 2024 out in the Lancet Infectious Diseases www.thelancet.com/journals/lan...
Tobias Warnecke
www.biorxiv.org
Tobias Warnecke
The 2024 WHO BPPL is a key tool for prioritising research and development investments
and informing global public health policies to combat AMR. Gram-negative bacteria
and rifampicin-resistant M tuber...
