I learned so much from watching past editions of @ccpem.bsky.social Spring Symposium, so I agreed to my talk being recorded even though this is stepping well out of my comfort zone (public speaking isn't my strongest skill). Anyway, here is the recording: www.youtube.com/watch?v=AKTf...
#CCPEM
New Preprint alert! Excited to share our latest work on the #MAPKinases from stellar PhD student Jill von Velsen. First structures of the MAP2K MEK1 activating its substrate MAPK between 2.9 and 3.6A - amazing resolutions for such a small and mobile complex! www.biorxiv.org/content/10.6...
Striking improvement with the laser phase plate to boost contrast, and in exactly the range that's needed for modelling the details of protein structures.
Still lots of headroom in Cryo-EM.
www.science.org/doi/10.1126/...
#biophysics
Phage receptor-binding proteins are known for their LEGO-like modularity, but we still do not fully understand their evolutionary potential and how it shapes phage host range. Our new preprint examines this systematically in Klebsiella phages. 🔗 www.biorxiv.org/content/10.6...
Thread 🧵
This, by @khinsen.net , is a very rewarding read. I've finally read it from the beginning to the end and found a lot to think about.
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes:
🖌️ Dozens more images with duplications or painting
🖨️ Hundreds of blots that all share the same background (behold slideshow below)
Excited to share the first pre-print from our lab!!
Check it out here! www.biorxiv.org/content/10.6...
We found that many RNA-binding proteins canonically understood to regulate RNA processing can also function like transcription factors and cofactors to directly regulate transcription.
Now online! Prion-based protein self-assembly tunes mutagenesis to enable rapid adaptation
With Eugene Koonin, we wrote a rather comprehensive review on the origin, evolution and organization of the #virosphere. We describe all 10 viral realms and the logic behind them, and so much more. Check it out! comptes-rendus.academie-sciences.fr/biologies/ar...
Prion-based protein self-assembly enables reversible switching of genome-maintenance pathways during rapid adaptation and the emergence of drug resistance.
New blog post: "Automating science" 🧪
https://
blog.khinsen.net/posts/2026/05/19/automating-science.html
How much of scientific research can be automated? And is this a good idea?
#metascience
We are looking for a postdoctoral candidate with experience in display techniques to co-write a fellowship application around a research program currently being developed within the team.
#postdoc #phagedisplay #antibodyengineering #proteinengineering #MSCA #ARCFellowship #CNRS
