How do wealthy parents help their offspring? By giving them ribosomes!
Optimal ribosome provisioning is key to fast development in unpredictable environments. The fastest path to ribosomal wealth in nematodes is a maternal inheritance.
Happy we could play a small part in this fascinating work.
Nick Stroustrup
New paper alert: Our latest shows how maternal diet impacts ribosome levels and early growth intergenerationally in #Celegans
Led by Sigma Pradhan and in collab with @nstroustrup.bsky.social
journals.plos.org/plosbiology/...
@plosbiology.org @izb-unibern.bsky.social @unibe.ch
Cells adjust their proteome to environmental conditions, but it remains unclear whether the proteome can be transmitted from parents to offspring. This study analyses the intergenerational effects of dietary restriction in C. elegans and shows that maternal mTORC1 activity governs the transfer of ribosomes, thereby modulating early growth and development.
