A British/American group leader at @crg.eu . We study the biology of aging using molecular genetics, engineering, systems biology, and probabilistic machine learning.
Lab page: http://lifespanmachine.crg.eu
Nick Stroustrup
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And of course, I remember his kindness of taking me on as a clueless engineering student and getting me a start in genetics. I only worked with him for a year, more than twenty years ago, but I still think about things he said.
David Botstein, 1942 - 2026.
www.online-tribute.com/DavidBotstein
Nick Stroustrup
Nick Stroustrup
The basilica, designed by Antoni Gaudí, becomes the world's tallest church with the inauguration of its central spire — the 566-foot-high Tower of Jesus Christ.
David was a beloved husband, father, brother, scientist, teacher, mentor, musician, friend, who touched the lives of thousands. David’s wide-ranging scientific career spanned decades with a legacy o…
It's very sad to learn of David Botstein's passing. I worked in David's lab as an undergraduate--one of the most formative periods of my academic life and probably the biggest reason I work in biology today.
I vividly remember my first meeting with David. I was a 3rd year engineering student,
hoping to learn what all the excitement was about, at the new genomics institute they'd just built on campus. I cold-emailed David looking for work, and a week later I was sitting in his office, learning about the principles of chemostats. I think I still have the little notebook drawing he made.
So while David is often remembered for his field-defining technological advances, e.g. restriction fragment linkage mapping and microarrays, what I remember most is the way he spoke and thought--integrating complex mechanistic detail with broader ideas about yeast physiology and metabolism.
-- New Open Research Game --
I reached the rank of Asst. Prof in #TenureRun! 🎓 I published 98 papers and paid $115.000 in APCs to publishers. My grant money is gone and I am exhausted. 💸 How far can you make it? Play now at forrt.org/TenureRun/
How do wealthy parents help their offspring? By giving them ribosomes!
Optimal ribosome provisioning is key to fast development in unpredictable environments. The fastest path to ribosomal wealth in nematodes is a maternal inheritance.
Happy we could play a small part in this fascinating work.
David was super smart and super direct, with a insistence on clear thinking that permeated everything he did. He could speak about "big picture" dynamical properties of cells, but he also had an encyclopedic memory-- ask him about any yeast gene and he'd tell you about it in fascinating detail.
Very cool!
We found 24 neuron classes that are excited or inhibited by environmental H2O2, spread across the nose, mouth, and inner pharynx. Different neurons trigger at different H2O2 levels (from 1 µM early warning to >1 mM lethal), and many adapt, so responses encode dose + recent history. 7/
