Improving the care of critically ill patients through investigator-initiated research. Pan-Canadian partnership of over 350 scientists, patient partners, health care professionals, research coordinators and learners. Established 1989.
Canadian Critical Care Trials Group (CCCTG)
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#CCR26 FISSH - quick trawl ...
In critically ill ≥16y requiring fluids for hypotension / organ hypoperfusion, with suspected infection, + ≤6h of ED arrival / ICU consult on ward, no difference in 30d mortality (Ringer's Lactate vs. normal saline, 33.6% vs. 33%; p = 0.80)
🐟 Coming up at 8:30 AM ET / 5:30 AM PT: results from the FISSH (Fluids in Septic Shock) trial
Join the #CCR26 Belfast livestream for the presentation and discussion:
criticalcarereviews.com
#CCR26 @dogicuma.bsky.social provides an editorial for the FISSH trial, and begins by describing the FISSH trial cohort as "the perfect septic shock population", highlighting the number of patients with bloodstream infection, and that ~90% patients receiving inopressors.
#CCR26 Srin Murthy presents the results. Reminds us of the importance of influenza, mechanism of Oseltamivir, the current recommendations for its use, and that there is no randomised evidence for its use
UNTIL NOW?!
#CCR26 FISSH - fluids were blinded!! Investigators made efforts to make it easier to enrol than not enrol.
Sample size: 35% baseline mortality; 8% absolute reduction; 80% power; p 0.05; 2% inflation ... n = 1118
