Excited to share our structural insights into how microtubules differentially guide phosphorylation of kinetochore-microtubule regulators, Ndc80 and MCAK, for chromosome segregation. Heroic efforts by Yiming Niu with a fun collaboration with Jennifer DeLuca lab!
www.science.org/doi/10.1126/...
Cryo-EM reveals how kinetochore-microtubule attachment is regulated by Aurora B substrate accessibility on microtubules.
Microtubules have been viewed as passive structural supports, but a study from @hirofunabiki.bsky.social in @science.org Advances redefines microtubules as active regulators, helping to prevent abnormalities in the number of chromosomes, a hallmark of cancer.
š: https://bit.ly/4v8miCC
