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NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K+ T cells: Immunity www.cell.com/immunity/ful... Excited to present Nancy's postoctoral work @ucsfaging.bsky.social @immunox.bsky.social defining the role of aging fibroblasts in driving inflammaging.
2mo
UCSF Peng Lab
Sharing JinYoung's latest work @ucsfaging.bsky.social @ucsfstemcell.bsky.social in collaboration with @lindsaylafave.bsky.social on how senescent fibroblasts program tumor plasticity and metabolism. JY is starting her own lab at Inha University. www.sciencedirect.com/science/arti...
7mo
Senescence has been demonstrated to either inhibit or promote tumorigenesis. Resolving this paradox requires spatial mapping and functional characteri…
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Senolytic-sensitive p16Ink4a+ fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity
UCSF Peng Lab
NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K+ T cells
Aging is accompanied by significant changes to the immune system. Allen et al. demonstrate that age-related NF-κB activation in fibroblasts remodels the lung resident immune system and promotes the em...
www.cell.com