Studying mitochondrial signaling and metabolism in the Chandel Lab at Northwestern University Feinberg School of Medicine.
Ram Chakrabarty
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new out in Nature www.nature.com/articles/s41...
Very happy to share our new paper. Together with our wonderful collaborators, we found that L-2-HG, a metabolite often viewed as “toxic,” also has an essential physiological function in mice. www.nature.com/articles/s41...
Nature research paper: Mitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite
go.nature.com/4tJN7ef
A key component of the TCA cycle, 2-oxoglutarate dehydrogenase, dictates the fate of intestinal stem cells during tissue regeneration @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Now online! Mitochondrial activity tunes nociceptor resilience to excitotoxicity
Modulating levels of a mitochondrial metabolite can direct intestinal stem cells to specialise for absorption or secretion
https://go.nature.com/3ZrJ0HI
Mitochondrial activity tunes nociceptor resilience to excitotoxicity: Cell www.cell.com/cell/fulltex...
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
We wrote a short post related to the paper: go.nature.com/4dRouYp
l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...
www.nature.com
l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...
Excitation enables neuronal function; however, overexcitation and calcium overload
can be deadly. This study reveals a cellular resilience program in which reduced expression
of electron transport cha...
l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and function.
Excitation enables neuronal function; however, overexcitation and calcium overload can be deadly. This study reveals a cellular resilience program in which reduced expression of electron transport chain components protects against excitotoxic death, as seen in pain-sensing primary afferent neurons (nociceptors).
A key component of the TCA cycle, a series of reactions that occurs in energy-generating organelles called mitochondria, can dictate the fate of intestinal stem cells.
Nature Metabolism, Published online: 08 May 2026; doi:10.1038/s42255-026-01530-yMetformin is shown to exert its glucose-lowering and additional clinical effects through inhibition of mitochondrial complex I in the intestinal epithelium in mice.
