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Do not miss this HIRA Hulk structure! 🤓👏👏
Looking forward to starting a new project with @bakkerslab.bsky.social to learn how chromatin changes to allow regeneration in the heart.
We are looking for a PhD student to study chromatin changes related to heart regeneration, in collaboration with @bakkerslab.bsky.social . Please share and apply! www.hubrecht.eu/nl/vacature/...
the deadline is rapidly approaching:
Group leader Miguel Leung has been awarded the Young Scientists Award 2026 from @heinekenprizes.bsky.social . With his group, he investigates the 3D structure of protein complexes, tiny machines at work inside each of our cells. Congratulations, Miguel! Read more: www.hubrecht.eu/heineken-you...
But wait! There’s more! So you thought you knew nucleosome structure? Think again! @vram142.bsky.social @gladstoneinst.bsky.social and @genophoria.bsky.social @arcinstitute.org show that there is plenty of distortion largely due to TFs butting in www.nature.com/articles/s41...
New work from Sashi Weerawarana on how TFAM compacts mitochondrial DNA 🧬 TFAM oligomerizes on DNA to form compact, homogeneous higher-order complexes (see beautiful mass photometry data below), that still retain dynamic behavior. Congratulations Sashi and Wei. www.biorxiv.org/content/10.6...
Here is the full 2026/27 program of @genomeiinetwork.bsky.social virtual seminars, chaired by myself and @dimiccolab.bsky.social. Scan the QR code to receive alerts and automated calendar. Don't miss a bunch of exciting talks from established and emerging leaders in genome integrity world-wide!
Our work on chromatin evolution in brown algae is now published in @natecoevo.nature.com! We show that developmentally complex brown algae evolved without epigenetic silencing pathways long thought universal, underscoring why non-model lineages are important to study. www.nature.com/articles/s41...
23d
2mo
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The newly established NeCEN Utrecht is looking for a #cryoEM scientist! www.uu.nl/en/organisat... Work with a new Krios 5 + pFIB and support cutting-edge life science research. 📍 Utrecht | 🗓 Apply by 30 April Please share with your network!
1mo
2mo
We are looking for PhD student in the group of Dr. Francesca Mattiroli at the Hubrecht Institute. The successful candidate will work in a collaborative project between the Mattiroli lab and the lab of...
www.hubrecht.eu
PhD student - 38 hours p/w - Hubrecht Institute
2mo
Francesca Mattiroli
Francesca Mattiroli
Francesca Mattiroli
Titia Sixma
Join our team to contribute to the operation and innovation of state-of-the-art cryo-electron microscopes and empower groundbreaking research.
www.uu.nl
Cryo-electron microscopy scientist
Hubrecht Institute
Benoit Bruneau
Karolin Luger
Lopes_Lab
An analytical pipeline called Iteratively Defined Lengths of Inaccessibility (IDLI) maps the genome-wide occupancy of a range of nucleosome types and shows that most nucleosomes exhibit programmed ‘di...
www.nature.com
Pervasive and programmed nucleosome distortion on single chromatin fibres - Nature
Michael Borg
Daniel Hurdiss
Congratulations! Jeroen den Hertog, @bakkerslab.bsky.social , @fmattiroli.bsky.social and Eva van Rooij received ZonMw Open competition grants to study RASopathies and heart regeneration. Read more here: www.hubrecht.eu/zonmw-grants...
2mo
Out today - structure of the human HIRA histone chaperone complex bound to nucleosomes. Ever wondered how nucleosomes are assembled in the wake of transcription? It takes a 'hulk of a protein complex'. Work by the amazing Wei Tian weetian558.bsky.social. www.biorxiv.org/content/10.6... 🧵
24d
Hubrecht Institute
Karolin Luger
We;re hiring Junior Group Leaders! 🔬✨ We’re looking for researchers in immunology, chemical biology, AI in biology, or protein design to launch their own independent groups in our collaborative, international environment. www.nki.nl/news-events/...
3mo
Netherlands Cancer Institute