Nature Reviews Genetics - In this Comment, the authors argue that understanding the genetic basis of adaptation requires considering the genetic architecture and ecological properties of traits...
rdcu.be
BREAKING:
New proposed OMB regulation, applying to all federal grants, requiring grant reviews by senior political appointees and re-emphasizes that "peer review remains advisory and does not replace agency discretion".
#standupforscience
public-inspection.federalregister.gov/2026-10817.pdf
More than two-thirds of the papers we've published since the lab started in 2019 have international co-authors, who have greatly enriched the science that we do
bsky.app/profile/jros...
public-inspection.federalregister.gov
Stand Up for Science!
Molly Schumer
Congratulations Jeff! It's been really wonderful to have you in the lab! I cannot wait to see all the fantastic work that will come out of your future lab.
...and trainees, Jeff is an amazing scientist and mentor! If you ever have a chance to work with him you should seize it with both hands!
The program for the 2026 New York Population Genetics meeting, hosted by at the @simonsfoundation.org on March 9th 2026, is now up: events.simonsfoundation.org/event/7c91dd....
So no publication fees, no conferences, no international collab, and we can terminate or reject your grant anytime for any reason. This might have some impact on how science works, folks. And maybe just maybe not a positive one.
My lab read this paper www.biorxiv.org/content/10.1... for journal club, and had some thoughts on the strong claims made about the number of signals of selection found.
Jeffrey Ross-Ibarra
For an update on our preprint about the mysterious signature SBS5, see: www.biorxiv.org/content/10.1.... New analyses throughout, but see Figure 5 in particular.
Jonathan Pritchard
Delighted to share our latest preprint: Julie Zhu identifies a surprising reason why the genetic architecture of brain-related traits is so different than other traits. Check it out!
Summary of Key Changes in OMB’s Proposed Federal Financial Assistance Rule.
Russell Vought is going destroy American Science.
elizabethginexi.substack.com/p/summary-of...
I'm excited to share that our work studying gene dosage response curves (GDRCs) is now out in Cell Genomics (@cellpress.bsky.social).
www.cell.com/cell-genomic...
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“The distribution of highly deleterious variants across human ancestry groups”. Preprint with Anastasia Stolyarova and @gcbias.bsky.social: www.biorxiv.org/content/10.1...
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
Milind et al. explore why loss-of-function variants and duplications tend to have
average effects in the same direction on 94 complex traits. Using gene dosage response
curves (GDRCs), they gather evi...
A major focus of human genetics is to map severe disease mutations. Increasingly that goal is understood as requiring huge numbers of people to be sequenced from every broadly-defined genetic ancestry...
I'm excited to announce that I'll be starting a lab at UCSF in the @ihgatucsf.bsky.social and @ucsf-epibiostat.bsky.social in July.
We'll work at the intersection of statistical genetics, population genetics, and machine learning.
