Is @nanoporetech.com hac v6 better than 5.2.0 sup? The short answer is no. But are a few errors in a genome worth 5 times more basecalling compute?
github.com/Kirk3gaard/M...
Excited to share our review relating to the giant extrachromosomal elements (ECEs)
We cover: why long-read metagenomics enables their discovery, genomic comparisons across recently characterized examples, and limitations of current classification tools.
www.cell.com/trends/genet...
New blog post!
I analyse the new [email protected] basecalling model from @nanoporetech.com and discuss the conspicuous lack of a new sup model:
rrwick.github.io/2026/06/11/d...
Prokaryotes harbor a diverse spectrum of extrachromosomal elements (ECEs), which are
intracellular replicons maintained independently of the primary chromosome. Historically,
the ECE research field ha...
Minibwa is a hybrid of bwa-mem and minimap2 and the successor of bwa-mem for short-read mapping. ~4X/2.5X as fast as bwa-mem/bwa-mem2 for WGS reads at comparable accuracy. Native support of directional bisulfite-seq. Applicable to long reads. Preprint at arxiv.org/abs/2606.15357
Excited to have Alex Crits Christoph @acritschristoph.bsky.social join the lab today as a staff scientist!
I had a hunch it was good time to find an experienced computational microbiologist to join the lab, but still feel very lucky to have him joining us. Looking forward to cool science!
𧬠New preprint! We clustered 5.6 million bacterial genomes into genomically cohesive units (GCUs) 500Γ faster than existing tools. (In just 14 hours, 16.5 GB RAM using 48 CPUs). π¦ πMeet gemsparcl πβ¨!
www.biorxiv.org/content/10.6...