Is @nanoporetech.com hac v6 better than 5.2.0 sup? The short answer is no. But are a few errors in a genome worth 5 times more basecalling compute?
github.com/Kirk3gaard/M...
Excited to share our review relating to the giant extrachromosomal elements (ECEs)
We cover: why long-read metagenomics enables their discovery, genomic comparisons across recently characterized examples, and limitations of current classification tools.
www.cell.com/trends/genet...
New blog post!
I analyse the new [email protected] basecalling model from @nanoporetech.com and discuss the conspicuous lack of a new sup model:
rrwick.github.io/2026/06/11/d...
Prokaryotes harbor a diverse spectrum of extrachromosomal elements (ECEs), which are
intracellular replicons maintained independently of the primary chromosome. Historically,
the ECE research field ha...
Minibwa is a hybrid of bwa-mem and minimap2 and the successor of bwa-mem for short-read mapping. ~4X/2.5X as fast as bwa-mem/bwa-mem2 for WGS reads at comparable accuracy. Native support of directional bisulfite-seq. Applicable to long reads. Preprint at arxiv.org/abs/2606.15357
Excited to have Alex Crits Christoph @acritschristoph.bsky.social join the lab today as a staff scientist!
I had a hunch it was good time to find an experienced computational microbiologist to join the lab, but still feel very lucky to have him joining us. Looking forward to cool science!
🧬 New preprint! We clustered 5.6 million bacterial genomes into genomically cohesive units (GCUs) 500× faster than existing tools. (In just 14 hours, 16.5 GB RAM using 48 CPUs). 🦠🐙Meet gemsparcl 💎✨!
www.biorxiv.org/content/10.6...
