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'Look, it's going to be an easy paper. Trust me. Six months. Tops'
Nov 18, 2024
1mo
New Preprint alert!🚨 Super excited to share my postdoc work now on BioRxiv. How does PRC2 loss lead to developmental failures? We combined rapid protein degradation with TLS embryoid models to uncover temporal and lineage-specific dependencies 🧬. Preprint: doi.org/10.64898/2026.04.18.719361
MadScientist
We are offering Postdoc & PhD positions 🥼 If you are interested in the intersection of X chromosome inactivation, epigenetics, aging, sex-biased disease, and allele-specific multi-omics, feel free to reach out or share this with interested candidates. More info: portal.mytum.de/jobs/wissens...
Big congrats to Julia! Besides doing amazing science, she has always been a super kind, supportive colleague. I can not wait to hear more about her cool work and so so happy for her for her new journey!
1mo
28d
Very excited to share our newest findings! A very long team effort pursued by multiple team members -to frantically reproduce everything over and over-, we show mTOR-Polycomb synergy at promoters of developmental master regulator TFs in ESCs prior to their expression. www.biorxiv.org/content/10.6...
1mo
Very excited to have Alex Meissner @molgen.mpg.de visit @upcite.bsky.social (jointly hosted by Pierre Defossez from the Epigenetics and Cell Fate Centre and me @ijmonod.bsky.social). If you want to see the cutting edge of DNA methylation in mammals, come to our big amphitheater on June 5!
Daniel MK Lee
1mo
This work came to life thanks to the incredible support from the Meissner Lab, the brilliant core facilities at the Max Planck Institute for Molecular Genetics @molgen.mpg.de, and the #MSCA fellowship. We had so much fun working on this project, and I hope you enjoy reading it.
Daniel MK Lee
1mo
I am extremely honored and grateful to see our work featured on PreLights @prelights.bsky.social. If you want a quick dive into how acute loss of PRC2 impacts TLS formation, check out this excellent breakdown by María @mariamafau.bsky.social. I had a great time discussing the work with her.🔬👇
www.biorxiv.org
A clear/significant finding derived from the single cell (sc) analysis of biological systems has been the realization that phenotypically homogeneous populations are heterogeneous at the level of gene expression (GE). www.cell.com/fulltext/S00... 🧵
23d
1mo
New paper out in @cp-cellstemcell.bsky.social. We uncover unexpected complexity in how metabolism changes when the embryo implants or when stem cells exit naive pluripotency, revealing a central role for dynamic TCA cycle rewiring in cell fate decisions. www.cell.com/cell-stem-ce...
1mo
www.cell.com
Daniel MK Lee
Using carbon tracing and functional experiments, Kafkia, Pladevall-Morera, et al. show that TCA cycle rewiring underlies mouse embryo implantation and the exit from naive pluripotency. In this context...