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This preprint is now out after peer review! Check it out: www.cell.com/cell-genomic.... Huge congrats (and thanks!) to the whole team that contributed!
May 21, 2025
Kolakada et al. discover that the amino acid preceding a premature termination codon influences nonsense-mediated mRNA decay efficiency. They identify peptide release rate during translation terminati...
www.cell.com
Systematic analysis of nonsense variants uncovers peptide release rate as a novel modifier of nonsense-mediated mRNA decay
Suja Jagannathan
Excited to share the latest work from the lab, led by Divya Kolakada, the first PhD from our group 🎓🤓🎉 Peptidyl-tRNA hydrolysis rate influences the efficiency of nonsense-mediated mRNA decay www.biorxiv.org/content/10.1...