Hello Fly Folks. quick note FlyBase is under duress due to termination NIH$ to Harvard and intl collabs. The hardworking folks @flybase.bsky.social are doing their darndest to ensure access to current data. For US, there will soon be a new site to donate. Please spread the word, ideas and support 🪰💪
www.biorxiv.org/content/10.6...
New preprint! We worked with @msftresearch.bsky.social and @broadinstitute.org to see whether large language models (LLMs) can be useful to variant scientists in deciding whether genetic variants seen in a patient are responsible for their disease. tl;dr yes they can: www.biorxiv.org/content/10.1...
Thanks also to our collaborator,
@zcoban.bsky.social for providing ASE data that helped us expand the scope of our findings!
Excited to have this out as a preprint!
It was a pleasure to work with @calhoujd.bsky.social and all the coauthors brought together by @varianteffect.bsky.social.
Excited for this work by Michael Cortazar, an @JagannathanLab Postdoc, to be out as a preprint.
So much hard work went into it, but it was well worth it 🤓
If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.
Please amplify. If you are also able to host fly strains, add your name as well.
This preprint is now out after peer review! Check it out: www.cell.com/cell-genomic.... Huge congrats (and thanks!) to the whole team that contributed!
Known for decades: DNA sequence drives nucleosome "rotational positioning" (which face of DNA contacts histones)
But: How does this persist when remodelers & transcription constantly mobilize nucleosomes? Our new preprint 1/ :
www.biorxiv.org/content/10.6...
Our latest work on targeting the poison exon in #RNA #splicing factor TRA2B in #cancer reveals a role for this non coding transcript and opportunities for targeting splicing factor levels across multiple tumor types
rdcu.be/d90Ra
#RNAsky @jacksonlab.bsky.social
