Rock Lab @ Rockefeller University. Tuberculosis functional genomics.
Rock Lab
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Reminder — UW #Microbiology has an open search for an Assistant Professor, focusing on fundamental problems in #bacteriology!
If you or someone you know would be suitable, here's the ad:
apply.interfolio.com/185622
A new study from Rockefeller's @victora.bsky.social in @cellpress.bsky.social reveals how germinal centers produce powerful antibodies through noisy rounds of mutation and selection, offering new insight into vaccine design—and larger themes in evolution.
🔗: https://bit.ly/3Sor6Ve
Huge congrats to @johnrubinstein.bsky.social on being elected a Fellow of the Royal Society! www.sickkids.ca/en/news/arch...
The @victora.bsky.social lab at Rockefeller has turned germinal centers into a living laboratory for one of biology's oldest questions: how much of #evolution is shaped by chance?
Learn more in this Q&A with Victora and graduate fellow Ashni Vora: https://bit.ly/4fB23bm
A new study from the @rocklabtb.bsky.social in @natmicrobiol.nature.com finds that one of the most common drug resistance mutations in #tuberculosis creates subtle metabolic weaknesses that could be exploited with future combination therapies.
🔗: https://bit.ly/3RG6wj2
Honored to have many projects and members of the lab’s research highlighted in the most recent issue of NU magazine @feinberg.northwestern.edu. Check out how folks in our lab are tackling the many challenges associated with Lyme disease! #microsky
magazine.northwestern.edu/discovery/ne...
Very excited about our recent preprint- @lindashuyingxu.bsky.social and collabs discover that neutrophils repurpose their nucleolus for storage of pre-made IFN-I to be rapidly released via a nucleolar stress response that results in nucleolar extrusion and secretion.
www.biorxiv.org/content/10.6...
Happy to share our latest preprint on the clonal dynamics of GC “refueling.” We asked what happens at the clonal level after the simple (and ubiquitous) step of delivering a second vaccine dose during an ongoing GC response.
www.biorxiv.org/content/10.6...
Alex Merz 🇺🇸🇨🇦🇺🇦
Rock Lab
The Rockefeller University
@agnese75.bsky.social's work is out. She shows that under iron starvation M. tuberculosis splits flux through the Krebs cycle and secretes metabolites, akin of fermentation. Why is this important? Metabolic flexibility is what makes it so hard to kill in vivo.
elifesciences.org/reviewed-pre...
Now open - LOIs for the Investigators in the Pathogenesis of Infectious Disease (PATH) program. Deadline is July 16 @ 3pm ET.
Faculty in US and Canada are eligible to apply
Grant Amount: $505,000 over five years
More information here: buff.ly/mBR4XST
#bwfpath
Brandon Jutras, associate professor of microbiology-immunology at the Feinberg School of Medicine, has been studying Borrelia burgdorferi — the bacterium that causes Lyme disease — for over a decade. ...
SickKids scientist Dr. Rubinstein has been elected a Fellow of the Royal Society for pioneering revolutionary imaging techniques to explore the structure and function of biological molecules.
