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@agnese75.bsky.social's work is out. She shows that under iron starvation M. tuberculosis splits flux through the Krebs cycle and secretes metabolites, akin of fermentation. Why is this important? Metabolic flexibility is what makes it so hard to kill in vivo. elifesciences.org/reviewed-pre...
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elifesciences.org
Mycobacterium tuberculosis partitions the Krebs cycle under iron starvation
Luiz Pedro Carvalho, PhD