More #CASP17 #RNA targets: OpenKnot @eternagame molecules from AI designers @rosettacommons.bsky.social @chaitjo.bsky.social & triphosphorylating ribozyme selected by Muller lab. All 8 RNA targets are non-natural — how will modeling methods do without MSAs, templates, homologous training examples?
First natural #RNA in #CASP17 is a group II self-splicing intron, and it’s also the season's 1st multistate target! Will server algorithms detect homologous group II intron structures to help modeling? Can servers model both unspliced and spliced states? predictioncenter.org/casp17/targe...
First two targets in #CASP17 are #RNA, and they're designs from the online videogame
@eternagame.org. Hope the bots preparing for CASP have been playing Eterna!
Results are in for @stanfordmedicine.bsky.social Kaggle #RNA 3D Folding, Part 2! Top teams team_cp and AyPy together just outperform the best template oracle, another milestone in computational biology. Come join the conversation as we prepare for #CASP17: www.kaggle.com/c/stanford-r...
The 17th Critical Assessment of Structure Prediction #CASP17 begins tomorrow. 2 #RNA targets per day for next few weeks! >60 servers registered already, including @kaggle teams. Join the fun at predictioncenter.org/casp17/
Latest #CASP17 #RNA targets are a tiny aptamer for tryptophan selected by Yarus lab @colorado.edu, a miniTTR by RNAmake @josephyesselman.bsky.social, and 2 singlet glycine riboswitches discovered by Breaker & Strobel labs. Note first one: 25-nt RNA by #cryoEM? predictioncenter.org/casp17/targe...
First public presentation of (Part 1 of) the #Kaggle 3D #RNA Folding challenge results -- see you Thursday!
The 2nd week of #CASP17 is closing, with more group II introns and some other RNAmake synthetic designs — the dimer targets for both kinds of targets seem challenging! And more #RNA targets are coming in week 3: predictioncenter.org/news.cgi#557
Third (& last?) intense week of #RNA server-only targets on #CASP17: small molecule binding ribozymes and aptamers & more group II introns in multiple states. Strange mix of natural and non-natural RNA and compounds and proteins. Looking forward to less crazy pace in next weeks.
predictioncenter.org
In 2 weeks, 9 Kaggle teams have beat AlphaFold 3 score (0.372) in predicting hidden 3D structures of #RNA, including complexes with small molecules & proteins. What will it take to beat the best template oracle (0.554)? www.kaggle.com/c/stanford-r...
Please join us for our next nucleic acid structure webinar, "Template-based RNA structure prediction advanced through a blind code competition," presented by Rhiju Das, G. John Rao, Toshiyuki Oda, Yehyun Kim, Raehyun Kim, Hyunkin Kim.
Mailing list: groups.google.com/g/casp-rna-sig
