RESEARCH
@morignypauline.bsky.social
@ondrej-kuda.bsky.social M Rohm (CAS, Helmholtz Munich)
Multi-omics profiling of cancer cachexia models uncovers a multi-tissue coordinated response🧪
📣 Check out our recent preprint on bioRxiv on cellular changes in adipose tissue in response to different weight loss modalities 📣
Multi-omics profiling of diverse cancer cachexia models uncovers a multi-tissue metabolite-coordinated response associated with disease progression and links multi-tissue one-carbon metabolism to wasting.
This work is the result of a collaboration between the groups of Maria Rohm @helmholtzmunich.bsky.social and @ondrej-kuda.bsky.social (CAS, Prague). I would like to thank all co-authors and reviewers.
Paper here 👇
www.nature.com/articles/s42...
Anne Loft
Pauline Morigny
New paper from our institute showing the importance of liver secretory function on the development of cancer cachexia. Congratulations to @dorie00.bsky.social , Sören Fisker Schmidt, Mauricio Berriel Diaz and Stephan Herzig ! Very proud to have contributed to this amazing story 🥳
Pauline Morigny
Weight Loss in Cancer: New research led by #HelmholtzMunich shows that #cachexia affects multiple organs in a coordinated metabolic way, not just muscles.
👉 Read more: t1p.de/q0ukw
@ondrej-kuda.bsky.social
@iphys-cas.bsky.social
@diabresearch-dzd.bsky.social
@dzhk.de
Hi Bluesky ! 🦋
I am proud to share our multi-omics study in cancer cachexia out in @natmetabolism.nature.com 🦀 Through metabolomics, transcriptomics and glucose tracing of multiple cachexia target tissues, we uncovered a metabolic pathway with pro-cachectic potential.
Pauline Morigny
Pauline Morigny
Helmholtz Munich
Preprint alert! We used snRNA-seq on adipose tissue from a longitudinal cohort of people undergoing surgury-induced weight loss. True ATLAS team effort
We found dramatic changes in immune and progenitor compartments. Give it a read and let us know what you think.
www.biorxiv.org/content/10.1...
