Thanks Eric! I worked to make this review of human immune memory to vaccines comprehensive and accessible. And I made an accompanying video lecture for those desiring a different format:
www.youtube.com/watch?v=8DeZ...
Here's the video lecture link:
www.youtube.com/watch?v=8DeZ...
In our latest study in @cp-immunity.bsky.social, we followed dynamics of vaccine-specific Tfh cells for 60+ weeks after immunization.
authors.elsevier.com/a/1m3mV3qNrU...
We captured >500,000 CD4 T cells including >36,000 vaccine-specific Tfh by scRNAseq, giving an unprecedented longitudinal detail.
Strong and functional GC-Tfh responses were associated with better antibodies, both in magnitude and quality. This suggests that effective vaccines can enhance Tfh responses that recruit and guide a broader B cell repertoire, ultimately driving antibody maturation toward neutralizing capability.
My new comprehensive review of Immune Memory to Vaccines is out! It has an emphasis on human vaccines. It is also accompanied by a full video lecture. Enjoy!
@lji.org @cp-immunity.bsky.social
authors.elsevier.com/sd/article/S...
We even detected same Tfh clones participating in different lymph nodes, suggesting a connected GC network.
We identified distinct subsets of GC-Tfh cells, including populations rich in IL-21 and IL-4, and with signatures of recent TCR engagement. We also spotted proliferating Tfh, Tfr, and IL10⁺ Tfh cells among others.
Together, this work shows that durable and robust GC-Tfh responses are key architects of high-quality antibody responses. They lead B cells toward their best performance.
Understanding how to sustain and shape these networks offers a path toward more effective and enduring vaccines.
We found that vaccine-specific Tfh cells expand early and remain active for months, showing no signs of exhaustion.
Tracking Tfh clones across weeks showed not only that the same clones can persist, but also how these different Tfh subsets are interconnected.
