Inlay

New review out! 😊 20 years after it’s discovery, with @iannaconelab.bsky.social we decided to bring together what we currently know about this cytokine and how it shapes CD8 T cell responses. A small contribution to make sense of a field that is moving fast 🌈 @cp-trendsimmuno.bsky.social

👀Sneak preview: watch the teaser of YASMINE BELKAID @pasteur.fr 🎞️ www.youtube.com/watch?v=_kUi... Join us for the #LJFPrizes Lectures: 📆22nd April 16h30 📍Auditoire Alex Müller (A250), Centre Médical Universitaire, Genève

Thanks to all for participating in the first EFIS sex differences in the immune system meeting, and thank you @darraghduffy.bsky.social @milieuinterieur.bsky.social for the generous hospitality and for inviting us to your fascinating annual meeting.

Congratulations to EMBO Members Yasmine Belkaid and Fiona Doetsch, who were awarded the Collen-Jeantet Prize for Translational Medicine and the Louis-Jeantet Prize for Medicine, respectively. https://www.jeantet.ch/en/ #LifeSciences #research #award 🧪

New review out in @cp-trendsimmuno.bsky.social! With @valentinavenzin.bsky.social, we revisit IL-27 as a central regulator of CD8⁺ T cell fate — integrating insights from infection, cancer, and autoimmunity, and outlining its therapeutic potential. www.sciencedirect.com/science/arti...

📣 Job opening in our lab! We're looking for a technician with experience in murine models. More details about the job description here 👇 www.linkedin.com/jobs/view/4353643662/

👩 @valentinavenzin.bsky.social alk is now on Youtube! CD4+ T cells license Kupffer cells to reverse CD8+ T cell dysfunction induced by hepatocellular priming youtu.be/sNsdPl6_RaU

Honoured to see our @natimmunol.nature.com study highlighted in a thoughtful @jhepatology.bsky.social commentary on the IL-27/Kupffer cell axis in chronic HBV — a great summary of why tissue immunity matters and of our work. Paper: tinyurl.com/yt652mxa Commentary: tinyurl.com/56pke5x5

This essay uses immunology to illuminate human relationships. Moving beyond self/non-self toward danger-based models, it draws parallels between cytokine communication and language, tolerance and forgiveness, microbiota diversity and coexistence. Recognizing these metaphors reveals pathways toward healthier connections within individuals, communities, and societies.

Valentina Venzin, (IRCCS San Raffaele Scientific Institute-Pasteur Institute) CD4+ T cells license Kupffer cells to reverse CD8+ T cell dysfunction induced by hepatocellular priming

Interleukin-27 (IL-27), a member of the IL-12 cytokine family, was long viewed primarily as a regulator of CD4+ T cell immunity. Subsequent studies revealed that IL-27 also directly modulates CD8+ T cells, displaying both stimulatory and inhibitory potential. Recent work extends this earlier literature, showing that IL-27 in infection and cancer can promote effector differentiation, sustain survival, and reverse dysfunction, often without the systemic toxicity associated with related cytokines. This review outlines the molecular features, signaling mechanisms, and cellular sources of IL-27, integrating emerging evidence from viral, tumor, and autoimmune settings. We propose that IL-27 operates not as an inherently pro- or anti-inflammatory cytokine but as a context-dependent tuner of CD8+ T cell cytotoxic immunity, offering new opportunities for therapeutic exploitation.

Here the authors show that CD4+ effector T cells prevent or reverse CD8+ T cell dysfunction by licensing Kupffer cells to trigger IL-27 production, defining a liver-specific immune circuit and a poten...