Penn Integrates Knowledge Professor, Natural Product Aficionado, Photopharmacologist, Fox Terrierist, Book Lover, and Unfulfilled Architect. #firstgen
Dirk Trauner
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Looking forward to hosting the Master of Symmetry.
What a week end at Penn! First we were honored to host Roald Hoffmann and then we ran the Chemistry 5K. La Vita e Bella.
Greetings from the Trauner Group Holiday Party!
I’ll ask
Opticial Control of Cholesterol, attempting to stay as close to the original as possible. Congratulations to Michael Zott, who defined and spearheaded this study, and to our wonderful collaborator Luca Laraia!
Excited to deliver the Overman Lecture next Wednesday at UC Irvine!
A big step forward in Photopharmacology, just published in Nature Medicine:
nature.com/articles/s41...
A compound we conceptualized in 2008 (PMCID: PMC4040390) and synthesized in 2010 (PMCID: PMC3401033) proves effective in human vision restoration.
Silyl protecting groups can function as dispersive directing groups, leading to unexpected stereoselectivities! Collaborating with Robert Paton, we have demonstrated this for a specific case. Stay tuned for a more systematic study!
pubs.acs.org/doi/full/10....
Vitamin D is famous for its photochemistry. We have now added a photopharmacology aspect in a wonderful collaboration with the Merk group.
onlinelibrary.wiley.com/doi/full/10....
Delighted to have collaborated with the @dirktrauner.bsky.social lab on the development and characterisation of #photoswitchable #cholesterol derivatives, now out in @jacs.acspublications.org! (1/3) pubs.acs.org/doi/full/10....
Dirk Trauner
Vitamin D exhibits complex and cell-specific biological effects in multiple tissues via activation of the ligand-sensing transcription factor vitamin D receptor (VDR). The photo-switchable vitamin D ...
Delighted to have collaborated with the @dirktrauner.bsky.social lab on the development and characterisation of #photoswitchable #cholesterol derivatives, now out in @jacs.acspublications.org! (1/3) pubs.acs.org/doi/full/10....
