Redox biology and cancer metabolism @ Moffitt Cancer Center. Views my own.
Gina DeNicola
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New preprint from the lab! Close collaboration with Silvia von Karstedt @vonkarstedtlab.bsky.social and her lab. We find that #SCLC cells are strikingly dependent on exogenous cysteine #LungCancer #CancerMetabolism #Ferroptosis 🧵
biorxiv.org/content/10.64898/2026.03.27.714827v1
Very interesting articles about cancer metabolism this month, and insightful reviews.
Highlighting fresh articles and comments about cysteine and glutathione from @lucasbsullivan.bsky.social @ginadenicola.bsky.social @harrislab.bsky.social and others
metabolist.wordpress.com/2026/05/04/m...
Second session at #CFM_MetCanc on the relationship between exercise, nutritional signals and cancer prevention.
Speakers:
Mark Febbraio, @monashuniversity.bsky.social
Gina DeNicola @ginadenicola.bsky.social, Moffit Cancer Center
✍️ bit.ly/45jaORu
Sponsored by @caixaresearch.bsky.social
Excited to announce that registration is officially open for #METPHYS2026!
All meeting details can be found here:
www.sablesys.com/metphys-the-...
Cystine / Glutathione / NADPH SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis Shanshan Liu (刘珊珊), Mark Gad, Caifan Li (李采蘩), Kevin Cho, Yuyang Liu (刘雨洋),…
metabolist.wordpress.com
Pleased to share our recent work out today in @natmetabolism.nature.com. This study addresses a longstanding mystery - NRF2-driven cancers increase cysteine acquisition (via xCT) by ~5x - so where does all that cysteine go?
Julien Sage
Cristina Muñoz Pinedo
Very helpful methods and protocol! www.sciexplor.com/articles/fos...
Great work @ginadenicola.bsky.social and team!
Hold the emails until after #AACR26.
Phillip White
Gina DeNicola
Lucas Sullivan
Muir Lab
Nature Metabolism, Published online: 07 April 2026; doi:10.1038/s42255-026-01499-8Previously uncharacterized cysteine-derived conjugates, including with endogenous sugar metabolites, accumulate in cancer cells with constitutive NRF2 activation and account for some of the increased cystine uptake that cannot be explained by conventional cysteine metabolism.
Accurate measurement of cysteine and related thiol-containing metabolites is essential for understanding cellular redox regulation. However, the intrinsic reactivity and instability of cysteine presen...
