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And, snapshots show ultrasonic excitation doesn't appear to compromise jet-vitrified sample quality, which is of course very important when particle concentration is low and every grid square counts!
We are pleased to release an update to this pre-print! Includes (1) proof-of-principle experiments on ultrasonic excitation during plunge vitrification, (2) cryo-ET characterisation of the effect, (3) and insights into grid/ice quality following ultrasonic excitation during vitrification.
New proof-of-principle experiments show ultrasonic excitation during conventional plunge vitrification yields better angular distribution for viral hemagglutinin, significantly improving our reconstruction resolution from 2.7 Å (in our jetting experiments) to 2.0 Å.
Cryo-ET further characterises the effect: in conventional samples, 50S ribosomal subunit particles appear to cluster at the bottom interface. But, under ultrasonic excitation, both interfaces are populated more evenly, with more particles free from either interface.
📢 We are now recruiting a PhD student in Structural and Molecular Virology in Sweden 🇸🇪
Work on RNA viruses using cryo-EM and in situ cryo-ET, with access to world-class microscopy infrastructure
Perfect for candidates with backgrounds in biochem, structural bio, and virology
More info ⬇️