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Preprint alert! 🚨 Presenting MHC1-TIP: a scalable, cost-effective workflow for MHC-I ligandome + proteome profiling from diverse samples, to for example uncover intratumoral heterogeneity in RCC. Spearheaded by Mayukha Bathini, and big thanks to all collaborators! biorxiv.org/content/10.1...
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Profiling antigens presented on MHC class I molecules on the cell surface is essential to identify candidate antigens for targeted and personalized immunotherapies. However, mass spectrometry-based im...
biorxiv.org
MHC1-TIP enables single-tube multimodal immunopeptidome profiling and uncovers intratumoral heterogeneity in antigen presentation
Rik Lindeboom