Ensembl 116 + Ensembl Genomes 63 are out! Explore new pig, cattle, and oat genomes, updated alignments and new VEP plugins
It’s a milestone! Our last on the current platform. New data from here on is via beta.ensembl.org
More info on our blog: zurl.co/MrJ2A
Ensembl
The recently-released rammap from Jeremy Wang and @lh3lh3.bsky.social is, indeed, looking like a strong contender to replace minimap2-rs in oarfish!
If you don't know David Hockney, check out his work. I especially love the winter -> spring transitions with a focus on light
Having a visual component when you are teaching a new concept is always something I value. I went back and redid some old diagrams as animations
This website has all mp4, gif and code for you to use yourself in slides of websites!
emilhvitfeldt.github.io/tidy-animati...
#rstats #quarto #dataBS
New preprint! Our workflow for processing single cell and nuclei data, called 🎉 scprocess 🎉 We have been working on it for ~18 months now, over which time we have processed at least 2k samples with it, so it has had a decent amount of testing.
Very excited to share our new review on the complexity of SMA genetics, now online @cp-trendsgenetics.bsky.social!
General interest in complex genetics? Want to know more about long-read sequencing? Segmental duplications? ✅✅✅
Have a look!
www.cell.com/trends/genet...
#rustbio 4.0 has been released. It harmonizes the error handling, improves the API, makes gap-open/extend behavior in pairwise alignment more intuitive and in-line with the literature, improves GFF parsing, and allows incremental building of the rank-select datastructure. github.com/rust-bio/rus...
Aggregating many experiments into one zero-shot protein language model score obscures that current models cannot meaningfully rank a set of fit mutations or prioritize new-to-nature functions
@clauswilke.com
www.biorxiv.org/content/10.6...
Video
Long-read sequencing, paralog-aware variant calling, and telomere-to-telomere (T2T)
human genome assemblies now enable the resolution of copy-, haplotype-, and nucleotide-level
complexities in segment...
4.0.0 (2026-06-12)
⚠ BREAKING CHANGES
Replace anyhow with typed thiserror errors (#674)
Change Phase conversion methods to use TryFrom for better error handling (#625)
for pairwise alignment, only...
github.com
Johannes Köster
Emil Hvitfeldt
Rob Patro
Will Macnair
Michael Love
Ewout Groen
Kevin K. Yang 楊凱筌
Jeremy Wang developed rammap, a minimap2 rewrite in Rust. It achieves comparable or better performance than minimap2 and produces identical output to minimap2. During rewrite, Jeremy found two long-existing bugs in minimap2 which are fixed in v2.31. www.biorxiv.org/content/10.6...
scprocess: a pipeline for processing, integrating and visualising atlas-scale single cell data #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.03.09.710141v1
