We found that Aβ fibrils at plaque edges form a complex with the U1 snRNP. U1-70k is the most-correlated insoluble protein with Aβ in AD. Previously thought to be intracellular in tangles, but we find it’s directly bound to Aβ. With @raflynn5.bsky.social. www.biorxiv.org/content/10.6...
www.biorxiv.org
Andrew Stern
Encouraged to see that the FY27 LHHS appropriations bill emerged from House subcommittee with a ~3% increase in NIH funding compared to FY26. But this needs to be more like 20% to make up for a decade of stagnation.
Andrew Stern
Updating this graph for the holidays 🎁
(datapoints are a selection of journals publishing in neuroscience)
My favorite NIH entity is the Council of Councils, which sounds like it might launch a war to defend Naboo.
Knowing little about this, I’d ask how complex matrix C (the FC map) is - how many baseline circuits and regions there are. If it’s only a few highly connected regions in few circuits (eg the DMN), then I see their point. If the # of circuits >> # patients and lesions, then LNM should be valid?
Introducing Nature Baubles, the latest addition to Nature Portfolio. open.substack.com/pub/andrewms...
